| Foot & Mouth Disease | Vesicular Stomatitis | Swine Vesicular Disease | Vesicular Exanthema of Swine |
| Cattle | Oral & hoof lesions, salivation, drooling, lameness, abortions, death in young animals, “panters”; Disease Indicators | Vesicles in oral cavity, mammary glands, coronary bands, interdigital space | Not affected | Not affected |
| Pigs | Severe hoof lesions, hoof sloughing, snout vesicles, less severe oral lesions: Amplifying Hosts | Same as cattle | Severe signs in animals housed on concrete; lameness, salivation, neurological signs, younger more severe | Deeper lesions with granulation tissue formation on the feet |
| Sheep & Goats | Mild signs if any; Maintenance Hosts | Rarely show signs | Not affected | Not affected |
| Horses, Donkeys, Mules | Not affected | Most severe with oral and coronary band vesicles, drooling, rub mouths on objects, lameness | Not affected | Not affected |
